In this episode of The Dana Parish Podcast, I sit down with one of TIME100’s most Influential Health Leaders, Dr. Ziyad Al-Aly. Dr. Al-Aly is a nephrologist/ epidemiologist & researcher at Wash U, renowned for his work in Covid and Long Covid. Here, we dive into his groundbreaking new GLP-1 study, published today in NATURE, which found unexpected benefits, and risks, of these drugs.
This is the largest GLP-1 study to date, conducted over the course of 4 years, encompassing more than 215,000 patients, and 2 million controls. We cover:
How GLP-1 medications work: mechanisms affecting weight loss, inflammation, and neurocognitive health.
Unexpected benefits: Reduced risks of Alzheimer’s, substance use disorders, seizures, psychosis, infectious diseases & more.
Side effects & controversies: GI issues like gastroparesis, pancreatitis, kidney injury, the need for longer-term side-effect data, and the debate over dependency.
Micro-dosing: The dose makes the poison, so is micro-dosing better?
Multisystemic Benefits: A possible treatment for Long Covid?
Obesity: The Mother of All Ills
Why Americans Are So Unhealthy: The role of ultra-processed food and how GLP-1s could transform public health.
The affordability crisis: Why high costs and limited access are preventing widespread benefits.
Elon Musk: He is taking a GLP-1 & stated how important he feels these drugs are to "health, lifespan and quality of life for Americans..."
Dr. Al-Aly doesn’t shy away from discussing the polarizing nature of GLP-1 medications, and addresses controversies and concerns surrounding these drugs.
Don’t miss this fascinating discussion about the drugs that could reshape how we handle chronic disease treatment and prevention.
💬 Join the conversation! What are your thoughts on GLP-1 medications & our discussion? Share your insights in the comments below.
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